The foundation of modern dermatology

Date of publication:2010-2   Press: People's health   Author:Zhang Xuejun Liu Weida He Chundi   Pages:1569  

In recent years, change rapidly progress, skin disease, skin disease theory is to supplement and perfect continually, basic research in dermatology as its clinical application is more and more attention. "Modern dermatology foundation" one book is the purpose of writing a novel, practical introduction to the basic knowledge for the vast number of Dermatology skin disease prevention and control workers tool. When writing the need to all levels of dermatologists and other professional medical workers, it is the advent of the subject based learning professional for skin system of science, timely understanding of the latest research trends and achievements in scientific research of this subject provides reference material a rich content. The system is strong, wide coverage, involving all aspects of basic field of Dermatology and Venereology, summarizes the main achievements of Dermatology; a strong lineup, as Chinese skin science a number of academic leaders. To write the book when they combine their research results and the relevant literatures published in recent years, new content and thorough analysis. The publication of this book for further basic research Chinese dermatology and Venereology will undoubtedly play a positive role in promoting.

"The foundation of modern dermatology (I)" and "modern dermatology Foundation (2)". "The foundation of modern dermatology (volume one) (Second Edition) (Hardcover)" adhering to the original layout style, but the specific content of the chapters have been updated, and timely increases in recent years new theory, new technology, new ideas and new methods. The book is divided into nineteen chapters, including the structure of the skin, the skin, the skin cell biology, physiology, biochemistry and molecular biology of skin, skin, skin immunology, skin photobiology, skin of pathogenic biology, medical mycology, skin pathology, the diagnosis of skin genetics, dermatology, foundation, sexually transmitted diseases, treatment of skin diseases skin pharmacology, toxicology, skin, skin disease, skin disease epidemiology, psychology sections of skin. "The foundation of modern dermatology (volume one) (Second Edition) (Hardcover)" in write mode to a comprehensive system, clinical and basic science should be relative, reflect the development characteristics of Department of dermatology. "The foundation of modern dermatology (volume one) (Second Edition) (Hardcover)" due to the skin venereal the abundant science related to the basic theory and knowledge, can be used as a professional doctor at Department of Dermatology essential reference, can also be used for graduate students and physicians continue to education and learning.
Author brief introduction

He Chun polyester, Professor, chief physician, tutor of doctoral students. Graduated from China Medical University in 1986, 1996 by the dermatology medical doctorate. From 1999 to 2000 the Free University Berlin in Germany. Research direction for science and genetics, immune biology immune pathological skin disease. Director, Department of Dermatology and Venereology First Affiliated Hospital of the China Medical University Key Laboratory of the Ministry of health of Immunodermatology first deputy director. As the Chinese medical association study group, vice chairman of the branch of experimental study, dermatology, Liaoning province of dermatovenereology branch chairman of Chinese Medical Association, Chinese Medical Association medical malpractice technical appraisal experts group of National Natural Science Foundation, the judges, China physicians Department of Dermatology Doctor Association member, Chinese Medical Association Medical Malpractice Technical Appraisal experts group "J Applied CostTletol"; (Europe) editorial, "Department of Dermatology" contributing editors, "China Journal of leprosy and skin diseases", "China Journal of Dermatology and Venereology", "Practical Journal of Dermatology", editorial board. For many years engaged in dermatology clinic, scientific research and teaching work, was named the Ministry of health talents, university innovation team leader of Liaoning province. Over 863 projects 1, 3 National Natural Science Foundation, Ministry of health talents special fund 1, the Ministry of Education Foundation in 1, the Liaoning province science and technology fund projects 1; and in two subjects (863 division responsible for the issue). Train 49 graduate students (11 doctoral students, 38 graduate students). Has published 98 academic papers, including 29 SCI papers (published in the "Natu re Getletics", ". ICMM "," BJD "etc.), editor, deputy editor in chief or editor planning teaching materials of Ministry of health, national college textbook" dermatology "(Seventh Edition), textbooks and monographs 8, main translation monograph" clinical dermatology diagnosis and treatment of color Illustrated Guide (forty-first Edition) ". Liu Weida, born in 1957 in Shanghai. In 1993 graduated from the Graduate School of Peking Union Medical College, a doctorate in dermatology. The Department of dermatology research Chinese Academy of Medical Sciences director of the fungal disease, skin disease, director of hospital, fungi, doctoral tutor. As vice chairman of the professional committee of China fungi microbiology society, vice chairman of the Chinese mycology society and director of medical mycology Committee, member of the Standing Committee of the society and mycological society of Dermatology Chinese group with traditional Chinese medicine and Western medicine, Department of Dermatology Chinese Association Branch member and mycological group deputy leader, the Chinese Medical Association Branch of mycology Department of Dermatology Deputy group leader, "China Journal of mycology", "Practical Journal of Dermatology" deputy editor in chief, "China", "Journal of Microbiology and immunology, Department of Dermatology," "Chinese Journal of infectious diseases", "China Journal of integrated traditional and Western Medicine", "Chinese Journal of leprosy and skin diseases", Journal editors. The main research direction for the medical fungi in molecular genetics, molecular diagnosis of deep fungal disease early, candidiasis vaginitis molecular pathogenesis, antifungal drug pharmacodynamics and clinical assessment, early subcutaneous fungal infection animal model and mechanism research. In recent years for the national science and technology project, the special sub major health ministry key clinical disciplines project, the National Natural Science Foundation of China, research funds reached 5000000 yuan. In the past 10 years, with the first author or corresponding author published more than 190 research papers, including 14 SCI papers. Editor of academic monographs "modern dermatology progress", edited 23 monographs. Zhang Xuejun, born in 1955. Professor, chief physician, MD, PhD supervisor. The current president of Medical University Of Anhui, Medical University Of Anhui Institute, skin of Ministry of education important genetic disease gene resources director of Key Laboratory of Department of Dermatology; International Association executive director, vice chairman of the Department of Dermatology, Asia Society of Chinese Medical Association dermatology and Venereology branch director, Chinese physicians dermatologist Association vice president and international famous SCl Journal of Department of Dermatology "J Invest Dermatol", "J Dermatol Sci" and "Int J Dermatol" editorial board. Was named the Ministry of health and young experts with outstanding contributions, the first batch of national key talent, the two level for the first. Dedicated to the study of genetic skin disease, and has chaired the national "863", "973" project pre research projects, National Natural Science Fund project, on the project more than 10, won the 2007 Annual National Award for science and technology progress award two, 2007 the Ministry of education of Natural Science Award, 2006 annual Chinese medical science and Technology Award 2005 year, Chinese medical science and technology award first prize and the 2005 year the Ministry of education for National Natural Science Award two prize. In the "Nat Gerlet", "Am J Hum Genet" and other journalsMore than 110 papers indexed by SCl, the cumulative impact factor reaches 300, the SCI paper cited more than 700 times. Editor in chief of national undergraduate textbook "dermatology" fifth, six, edition and the national medical graduate textbook "in English medical research paper writing and submission" first edition. The sixth edition of "dermatology" won the first prize of national excellent textbook of higher medical.
Catalogue of books

The first chapter of the skin (skin embryology) section a, epidermal keratinocytes, melanocytes occurred in two of three, Langerhans cells occurred in four, Merkel cells occurred in second day of skin and appendages, hair follicle and hair occurred in two, eccrine sweat gland apocrine sweat glands, three, four sebaceous glands five, finger (toe) in section three leather fourth festival really. Epidermal junction occurred in fifth day embryos at various stages of skin characteristics, embryonic skin two, embryo to the fetal skin change three, four fetus, fetal skin biopsy and prenatal diagnosis in sixth human skin during embryogenesis the main events of the time period the second chapter structure of the skin, first day of epidermal keratinocytes, melanocytes, two three, second four Langerhans cells Merkel cells festival really epidermis third leather one, collagen fiber, reticular fiber three, two four, five elastic fiber matrix, dermal cell components fourth section fifth day subcutaneous tissue of skin appendages, hair and hair two, Mao Nangsan four, sebaceous glands, eccrine sweat gland five, apocrine sweat glands six, a sixth day skin Skin nerve section seventh of the blood vessels in the skin eighth skin lymphatic section ninth skin muscle section tenth transitional parts of skin and mucosa histological, lip, oral mucosa of two three, four, and five penis labia, clitoris nipple and areola third chapter skin cell biology section 1 of keratinocyte biology, horny the formation of basic cell biological characteristics of two, keratinocyte proliferation, differentiation and regulation three, keratinocyte apoptosis and its regulation four, keratinocyte tumor transforming five, keratinocyte self protection six, keratinocyte cell signal transduction seven, keratinocyte immunological function eight, keratinocytes and the relationship between the nine, other cells to keratinocytes primary lesions of skin diseases in ten, keratinocyte research method in section second of melanocyte biology of melanocytes, the basic biological characteristics of two, melanocyte proliferation, differentiation and regulation of melanogenesis in three, melanocytes and keratinocytes. Four, the relationship between melanocyte associated skin diseases, melanocytes five basic research methods in section third, Langerhans cells Biology a cell biological characteristics, Langerhans two, Langerhans three, skin cells and immune function of Langerhans cells and other cell interactions between four, skin diseases in Langerhans cells, Langerhans cells change five basic research methods in fourth Merkel cells and undifferentiated cell biology, basic biological characteristics of Merkel cells, two Meekel cells and other cells, skin diseases and three changes of Merkel cells four, undetermined cells of fifth day dermal fibroblasts, fibroblast biology related title or two cells, fibroblasts on basic biology three, dermal fibroblasts and other cells or the extracellular matrix interaction four, dermal fibroblasts of five basic functions, dermal fibroblast heterogeneity six, fibroblast related skin disease seven, fibroblast basic research method in section sixth, dermal microvascular endothelial cells, endothelial cell biology basic biological characteristics of two, endothelial cell proliferation, angiogenesis and its regulation three, endothelial cells and skin inflammation and immune four, vascular endothelial cells and cells Extracellular matrix interactions five, endothelial cells and skin disease six, human dermal microvascular endothelial cell isolation and culture method of section seventh cutaneous mast cell biology of mast cells in the skin, the basic biological characteristics of two, skin mast cells and inflammatory mediators in three, big cell immune function in four, and skin mast cells disease of the skin, five skin mast cells of eighth day skin nerve cell biology, skin nerve cell formation and characteristics of two neurons and neurotransmitter, three, skin disease of nerve cell changes four, cutaneous nerve cell the basic research methods in section ninth, skin fat cells, fat cells biology basic biology characteristics of two, adipose derived stem cells three, fat cell proliferation, differentiation and regulation four, fat cell and fat metabolism, skin diseases and five fat cells, fat cells change six basic research methods in section tenth hair follicles, sebaceous gland, hair follicle biology, sebaceous cell composition and characteristics of two, hair follicle development and hair growth regulation three, to the hair follicle and sebaceous gland, as the main lesions of the skin disease, skin, hair bag four The sebaceous glands of the basic research methods in section eleventh, the wound repair of skin cell biology, tissue repair and regeneration of skin wound healing in two, three, the basic process of skin wound healing process in cells, cytokines and extracellular matrix four, skin wound healing in five, abnormal fetal skin wound without scar repair, six skin wound repair research significance and Enlightenment of the fourth chapter skin physiology section one the skin barrier function and absorption, the anatomical basis of a barrier, barrier two physiological basis of skin barrier function of three, four, five, skin absorption of skin barrier function and absorption factor of second skin secretion and excretion, sweat glands, sebaceous glands, a two third day skin temperature regulation function, temperature two, body heat balance three, temperature regulation fourth skin sensation, skin feel classification two, skin feels electrophysiological three, skin feel and nerve conduction relationship four, skin sensory threshold of five, skin six, the skin feeling feeling after seven, several common skin feel fifth skin immune function, skin on the immune Endocrine function development of the role of two, skin immune system three, skin immune surveillance function sixth day skin respiratory function a, carbon dioxide two, percutaneous oxygen partial pressure seventh section of skin of a, steroid two, protein and peptide three, thyroid hormone, vitamin D hormone four...... The fifth chapter sixth chapter skin skin biochemistry molecular biology immunology eighth chapter seventh chapter skin skin photobiology ninth chapter: Chapter tenth skin of pathogenic biology medical mycology skin pathology eleventh chapter twelfth chapter thirteenth chapter skin genetic skin disease diagnosis fourteenth chapter of sexually transmitted diseases in fifteenth chapter dermiatrics sixteenth chapter seventeenth chapter skin skin pharmacology the eighteenth chapter skin toxicology psychology nineteenth chapter of skin diseases in English Chinese onAccording to the index
Chapter excerpt

Illustration: mannan (mannan protein complex) is a kind of polysaccharide content in the highest fungal cell wall, a polysaccharide is the most important, have not yet found a mannan protein deficient mutant. The epitope composition is an important target for the diagnosis of fungal disease. Cell wall glycoprotein dermatophytes, Aspergillus fumigatus (such as galactomannan peptide and glucose of mannan peptide) is a specific antigen induced host skin allergy. The molecular weight of mannan protein can be up to above 200000 Dalton, the chromatographic analysis of enzymatic hydrolysis can be divided into 5 different components, the structure of mannan 90% mannose, 10% protein, there are a few of the P. With different protein and phosphorus contents of different strains. In a short 10% mannose oligosaccharides form, the serine and threonine residues are connected, the remaining 90% by aspartic acid amine and protein N acetyl glucose in. The lipid content of about fungal cell wall matrix 8% of dry weight, lecithin, especially in the unsaturated fatty acid is more, minority and polysaccharides, proteins into a complex aggregation in the cell wall of the inner layer. The most content of cell wall usually in aerial mycelium, fruiting body, conidia, the existence of lipids can keep the water does not evaporate. The main component of inorganic salt as phosphorus, with fat, sugar content as much. Another little calcium and magnesium. Studies on fungal cell wall with chemical analysis method, using cell wall specific enzyme degradation of specific polymers, and electron microscopy to observe. In Neurospora crassa as an example, the cell wall of each layer of chemical components are as follows: the outer layer is amorphous dextran [p (1-3)] and [p (1 - 6), the thickness is about 87nm; the rough network II glycoprotein formation, buried thick 49nm in the matrix, the protein layer, about; 9nm; the innermost layer is chitin radial arrangement of micro fiber, may also have protein, about 18NM thick; the plasma membrane. (two) the diaphragm or interval, is located in the hyphae or between cells, is a kind of evolution of fungal evolution to adapt to the environment. Different kinds of diaphragm with genus, which can be used as the basis for classification. Complete interval lower fungi hyphae of fungi, with the evolution of small, ranging from the size of the emergence of interval. The skin of filamentous fungi, dematiaceous fungi, histoplasmosis, coccidioidomycosis. As well as sporotrichosis mycelial interval of a center hole, and a spacer bodies. Flow rate in this hole and the body can regulate hyphal cytoplasm interval on both sides, and when the mycelia were mechanical injury can plug the hole to prevent the loss of cytoplasm. Mycelia of basidiomycetes separated in a barrel structure special, obvious uplift holes visible around with, and a two dumbbell like shape, a barrel cover pad, the small hole in the middle is very narrow, so as to prevent nuclear mobile, this is the important feature of basidiomycetes, can be used as one of the basis for classification. (three) the cell membrane and organelle cell membrane of 1 fungal cell membrane and observed under electron microscope and all biological unit membrane, a fluid mosaic model, with the typical three layered structure, main components of the phospholipid molecules, it regularly arranged into two layers, but is not constant, often forming micelle structure; protein is amorphous molecular, non symmetrically arranged on both sides of the phospholipids, and the particles are not evenly distributed, and a mosaic. In addition the sterol inclusion in between the phospholipids and phospholipid, the ratio of 1:5 to 1:10, and is easy to be combined with cholesterol polyene antibiotics, are the molecular basis for antifungal drug action. The carbohydrate content in fungal membrane was higher than that in other organisms, in general biological below 10%, and the content of Candida albicans hyphal can account for 25% of the dry weight. Fungi are the only organisms with high carbohydrate content. 2 fungal cell nuclei than other eukaryotic nucleus is small, the general diameter of 2 ~ 3 bucket m, individual large nuclear diameter of up to 25m. Nuclear shape changes a lot, usually oval, can pass through the hole on the diaphragm, can quickly move in the mycelium. Changes in the number of different fungal nucleus is very big also, still do not know what factors determine the percentage of nuclei and cytoplasm. Hyphae in apical cells often can not find the nucleus. With the difference of fungal microscopy of living cells, can see the center populated area, the nucleolus, surrounded by a layer of uniform no obvious structural core, outside there is a double nuclear membrane, the outer membrane often ribosome attachment. A small nuclear membrane, the number of holes increases with age. Fungal membrane has been existed in the nuclear division, which is different from other higher organisms. Chromosome fungal nucleus is small, not easy to dye, so the conventional cytology analysis method is not easy to analyze. In recent years, many scholars have studied fungi chromosome DNA, nuclear DNA was determined by various experimental methods of size (6 ~ 30) × 10kA, compared to other higher plants and mammals is much smaller. IWe have used the pulsed field gel electrophoresis separation of 8 kinds of common pathogenic Candida and Cryptococcus neoformans and several yeast chromosomes, the number and the size, laid the foundation for further study on molecular genetics of.
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