Eczema is a common disease in Department of Dermatology, atopic dermatitis is the typical representative of this kind of disease. Atopic dermatitis due to defer does not heal, repeated attacks with severe itching, seriously affecting the patient and family life quality. The disease prevalence in industrialized countriesRate is very high, up to 15% ~ 20%. Therefore, atopic dermatitis has become allergic inflammatory skin disease research in the field of the most significant progress, knowledge updating and clinical research base of the fastest. China's atopic dermatitis incidence is relatively low, and because of a late start, lack of comprehensive understanding, often the atopic dermatitis as general dermatitis eczema, and ignore the treatment of this disease. With China's rapid economic development and the accelerated process of industrialization, the incidence rate is rising. To strengthen the study and understanding of the disease, avoid similar happens in China in industrialized countries with high incidence, is an important subject in front of our scientific workers in front of the skin. Professor Hao Fei prepared by the "atopic dermatitis" with reference to domestic and foreign literatures in recent 10 years, involving of atopic dermatitis in etiology, epidemiology, pathogenesis, clinical manifestations, animal model, diagnostic criteria, severity of illness, treatment means and evaluation of health education in many aspects, especially is the research results and method of re in clinical practice. At the same time, much of the content of this book is also valuable for other types of dermatitis eczema. That book, for the promotion of skin diseases in our country academic colleagues on the understanding of the disease, clinical diagnosis and treatment standard of this disease, strengthen a positive role in promoting prevention. You can believe that, with joint efforts of colleagues, our dermatitis eczema in basic and clinical research work will be the last new step.
"Atopic dermatitis" according to the features of atopic dermatitis and progress of clinical research based fast, new achievements, the extensive collection of up-to-date literature, combined with his own research results and rich experience in clinical practice, the use of modern molecular biology, genetics and immunology theory, divided into 22 chapter elaborates the atopic dermatitis in the etiology, pathogenesis, epidemiology, animal model, clinical manifestation, laboratory examination, diagnosis, differential diagnosis, treatment and evaluation of prognosis of the disease, and health education, etc.. There are topical corticosteroids and calcineurin inhibitor evaluation, specific immunotherapy, allergen detection and specification, pruritus, phototherapy treatment application, and Chinese medicine hot content. "Atopic dermatitis" novel content comprehensive, theoretical, practical, suitable for dermatologists to read, but also for the related professional graduate, medical students learning reference.
The first chapter is introduction section of atopic dermatitis concept understanding, named two, basic concept and understanding of the process of three, allergic rhinitis and atopic relations section second atopic dermatitis, asthma, allergic rhinitis, comparison of experimental and clinical evidence to compare two, commonness and individuality is section third atopic dermatitis research status, research status abroad two, domestic research situation, problems and Prospect of the three chapter second atopic dermatitis etiology section of atopic dermatitis and the genetic, genetic factors on the onset of action of two, the incidence of genetic research, animal model to study the three section second atopic dermatitis, and allergen inhalation two, food allergens and allergen in three, four, five chemical allergens insect allergens, biological allergens in third atopic dermatitis and microbes, two Staphylococcus aureus, herpesvirus three, Malassezia four, Candida albicans, five dermatophytes, fungi six section fourth other atopic dermatitis related one of the factors, environmental factors, three factors two occupation, social status and way of life of four, five, six, family pressure, stress the third chapter atopic dermatitis epidemiologic section The basic concept, two, three, the development of atopic dermatitis in epidemiological study of second day popular features, time distribution, geographical distribution of two three, age distribution, sex distribution, four five race distribution section third risk factors, genetic factors, environmental factors of three, two, four, social economic factors of mental factors five, living habits, infection factors of six section fourth trends in the incidence of a disease stage, changes of two, population structure change three, fifth section of allergen sensitization changes on social, economic impact _ fourth chapters in the pathogenesis of atopic dermatitis skin barrier function in the first section, the normal skin barrier function, skin barrier function evaluation of three two skin barrier, abnormal pathophysiological base four, skin barrier abnormality and pathogenesis of second abnormal cellular immunity and its mechanism, immune effect cell dysfunction and abnormal two, cell immunity abnormality and disorder mechanism third abnormal humoral immunity and its mechanism, serum immunoglobulin disorders and abnormal B cell activation in two, IgE skin inflammation _ three, lgE and atopic dermatitis of autoimmune disorders four, super antigen in humoral immune disorder in the role of The fourth section keratinocytes, inflammatory pathogenic role of a magnifying effect two, the activation of KC cell factor three, the activation of KC excessive secretion of inflammatory factors and molecular mechanism of KC four, involved in the pathogenic mechanism of the other fifth antigen presenting cell pathogenic role, antigen presenting cell types and distribution of two, IgE binding receptor expression and functional regulation three, therapeutic targets sixth mast cells and basophils pathogenic role, two, a pathogenic characteristics of mast cell and basophil differentiation three, mast cell and basophil secretion medium four, mast cell and basophil activation five, two these cells involved in the pathogenesis of evidence six, therapeutic targets seventh eosinophils pathogenicity, eosinophils and atopic dermatitis in two, eosinophilic regulation three, eosinophil chemotactic mechanism four, granule protein release five, eosinophils and IgE mediated late phase reaction of six, a therapeutic target for eighth atopic dermatitis and Thl / Th2 imbalance, a helper T cell type two, atopic dermatitis in Thl / Th2 mode three, regulation of atopic dermatitis Thl / Th2 differentiation mechanism of four, Th in lesional skin cell chemotaxis mechanism five, balance treatment of ninth inflammatory cytokines and mediators, cytokines pathogenic role of a two abnormal, chemokines and atopic dermatitis in three, other mediators of inflammation and atopic dermatitis tenth non immune factors, pathogenic role in a spirit of two factors, endocrine factors, the fifth chapter three metabolic factors of atopic dermatitis in animal model of section a, atopic dermatitis, two markers of disease progression in three, research status, research significance of four animal models of second section of natural animal, a rat model of system two, the dog model of system third allergens or chemically induced animal model, dust mites and extract two or three - 4 or two - 4 three, food antigen induced model fourth transgenic animal model, two IgE transgenic mice, IL4 transgenic mice in the sixth chapter of atopic dermatitis in clinical manifestations of the seventh chapter of severe atopic dermatitis program evaluation of the eighth chapter of atopic dermatitis the ninth chapter material laboratory examination of atopic dermatitis in diagnosis of the tenth chapter of atopic dermatitis in differential diagnosis of the eleventh chapter of atopic dermatitis patients, complications and related comprehensive In the twelfth chapter of atopic dermatitis TCM understanding and identify the thirteenth chapter the treatment of atopic dermatitis in Fourteenth chapter introduction of atopic dermatitis in the general treatment of the fifteenth chapter of atopic dermatitis, pruritus and antipruritic therapy sixteenth chapter atopic dermatitis glucocorticoid topical therapy seventeenth chapter atopic dermatitis topical calcineurin God by phosphoric acid resist agent evaluation eighteenth chapter of atopic dermatitis in nineteenth chapter system drugs in the treatment of atopic dermatitis photochemical therapy will chapter twentieth atopic dermatitis have specific immune therapy twenty-first chapter atopic dermatitis have some new biological therapy twenty-second chapter atopic dermatitis course and will turn to the appendix
Three, the problems and prospects of (a) genetics and environmental factors interact as everyone knows, atopic dermatitis and genetic related, but so far, the lack of sufficient evidence to support one or a set of genes that determine the occurrence and development of atopic dermatitis. As the object of study, especially the selection of different age, sex, race, has affected the analysis and pathogenesis related gene polymorphism. Therefore, it is difficult to clearly related gene and its function key, it is difficult to carry out the development of gene therapy and control disease fundamentally. Interaction between gene polymorphisms and environment factors, but also special studies should be another concern dermatitis genetics. Given the large number of research and analysis, environmental changes may affect the development of atopic dermatitis and outcome, how environmental factors and genetic basis of together, to analyze the interactions may be an important subject in the future study. Believe that with the molecular genetics and molecular immunology theory and technology constantly updated, is expected to change the current isolated on various predisposing risk genes and environment factors, the research on Mechanism of atopic dermatitis conforms to actual clinical situation, but also for atopic dermatitis etiology therapy and other therapeutic basis provide valuable evidence. (two) a variety of clinical manifestations and diagnostic criteria are not uniform in atopic dermatitis clinical manifestation is complicated, not only the existence of skin lesions complicated, also combined with various skin symptoms, the suspicion that the disease is not an independent disease, but a syndrome. The clinical manifestation is a typical lesions of different stages of change, can also be manifested as atypical changes in lesions, especially adult atopic dermatitis. Mixed type can be expressed with respiratory allergy history, also can appear only as simple type of skin involvement, endogenous or clinical and experimental examination of the lack of allergic evidence, it proposed greater challenges to the clinical recognition and diagnosis. So far, the laboratory is the lack of any clear or negative indexes of atopic dermatitis was diagnosed according to the diagnostic criteria, often domestic, foreign development to establish the diagnosis, it is to establish the diagnosis standard put forward higher requirements. At present there is no accepted diagnostic criteria for clinical diagnosis and epidemiological investigation. Therefore, actively promote the understanding of the clinical manifestations of L for atopic dermatitis, continuous improvement and unification of existing diagnostic criteria, to guide the rational treatment of atopic dermatitis is very important. Look in line with the world of different types of atopic dermatitis was diagnosed standard will soon emerge as the times require. (three) research and disease treatment method of effective control over the past 20 years, the treatment of atopic dermatitis model has been changed greatly, has simply from the use of corticosteroid dosage immunosuppressive and anti-inflammatory treatment, have turned to restore skin barrier, the selective use of immunosuppression or immune modulators and phototherapy and three-dimensional treatment mode. However, there is an undeniable fact, there is a lack of safe and effective control of atopic dermatitis in the occurrence and development of methods. Specific immunotherapy is a highly regarded from the perspective of etiology prognosis method, however, because of the long course of treatment, the effect is not sure to meet the clinical needs. Future needs to change the specific immunotherapy strategies, provides a multivalent allergen preparation techniques and methods, the improved immune pathways, and combined with other immune modulators, so that the specific immune therapy to obtain the maximum benefit. Atopic dermatitis is inflammation of allergic a combined with skin barrier dysfunction characterized. So how to improve skin barrier function, blocking a pathophysiological link disease, is the future of therapeutics on another hot spot.
"Atopic dermatitis" with reference to domestic and foreign literatures in recent 10 years, from atopic dermatitis in the etiology, epidemiology, pathogenesis, clinical manifestations, animal model and other aspects of the book were introduced, especially the achievements and methods of re on clinical guide. At the same time, "atopic dermatitis" many content also has guiding value for the other types of dermatitis and eczema.
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